Can't help you with the sound issues I'm afraid, I've not seen any problems like that myself.
As for controlling the mix, if you have any experience with editing panels the easiest thing is to add an EGT or a fuel flow gauge to one of the panel pop-ups. Personally, since I use the C47 for my Airhauler company, I find the fuel flow gauge most useful, so I've added this and a working ADF - actually I've removed whatever used to come up with Shift-F6 because it already worked perfectly well from the VC (maybe a throttle quadrant or electrical panel?) and replaced it with a dual engine fuel flow and endurance calculator and the aformentioned ADF. I think I got the fuelflow gauge from flightsim.com, and although it works well I did have to edit the gauge itself because it was originally set up for jet fuel instead of avgas. (Clearly this approach is rapidly becoming pretty rubbish advice unless you're comfortable tweaking things. Sorry about that. If you're still interested I'm happy to answer any queries for a fellow DC3 jock...)
As I understand it, in the real thing the mixture controls have 4 detents so that rather than making subtle changes one simply picks from Idle/Cut-Off, Auto-Lean, Auto-Rich and Full Rich, depending on the situation. However, I find that if I try to fly like this FSX won't shut up complaining that I'm at the wrong setting, hence me making the effort to add the gauge! Now, if I could just figure out how to hack the VC CHT gauge to read properly...
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